Ryan Griffen is best known as the creator of the twelve-part high concept sci-fi series CLEVERMAN about Aboriginal superhero Koen, which premiered at the Berlin Film Festival and screened at Series Mania in Paris. The series premiered in Australia on the national broadcaster ABC (Australian Broadcasting Corporation), on Sundance TV and Netflix in the USA and on the BBC in the UK.

In 2018, Ryan became the first artist in residence at Start VR, working with producers Nathan Anderson and Carolina Sorensen to create new narrative works supported through the Screen Australia Enterprise Ideas program.  Ryan is currently writing two graphic Novels: Cleverman and Lustration for Gestalt Publishing and has several feature film and television series in development.